5-HT Receptor Inhibitor
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About 5-HT Receptor Inhibitor

5-hydroxytryptamine (5-HT), also known as serotonin, is a heterocyclic amine that participates in the regulation of various physiological functions and pathological states in the brain, and is a substance that plays an absolute role in the process of emotional regulation in the brain. The role of 5-HT in the brain is closely related to the distribution of 5-HT neurons in the central and peripheral nerves and a large number of different types of 5-HT Receptor (5-HTR). At present, there are seven types of 5-HTR, some of which can be divided into several subtypes. Except that 5-HT3R belongs to ligand gated cationic channel, the other receptor subtypes belong to G protein-coupled receptor superfamily. 5-HTR mediates a variety of physiological functions, including regulation of emotion, in which 5-H1AR, 5-HT2AR, 5-HT2CR, 5-H3R and 5-HT7R are closely related to depression.

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