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About CD155 Inhibitor

An Overview of CD155 CD155 is a highly glycosylated type I transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF) member. As an important tumor-associated protein, its aberrant expression has been confirmed by a large number of studies on tumor invasion and metastasis and the anti-tumor effect of regulating immune cells. The human CD155 molecule was first discovered by Bernhardt et al. in 1989. This molecule can mediate poliovirus (PV) invasion of the body and cause polio, hence it is named poliovirus receptor (PVR). CD155 is involved in cell proliferation, apoptosis and motor processes. IgSF member CD155 belongs to the Nectin family in adhesion molecules. It is involved in the formation of cell adhesion and adhesion junctions (AJs) and plays an important role in mediating the metastasis of malignant cells. Due to the difference between CD155 and Nectins, Takai et al. named CD155 as Necl-5 (Nectin like molecule-5) in 2003. Studies found that CD155 is also involv

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