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About CD4-Gel immunotoxin

This immunotoxin was achieved by conjugating/fusing the CD4 to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells infected with HIV. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of AIDS.

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