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About GITR Inhibitor

An Overview of GITR Glucocorticoid-induced tumor necrosis factor receptor (GITR) is the 18th member of the tumor necrosis factor receptor superfamily (TNFRSF) and is a surface molecule of CD4+CD25+ regulatory T cell (Treg) from thoracic gland. GITR belongs to members of TNFRSF with CD40, CD27 and OX40. Its intracellular region is homologous with these members, and extracellular domain is rich in cysteine motifs. GITR is a homologous dimer transmembrane glycoprotein of 70kD, mainly expressed on resting Treg cells in thymus and peripheral lymphoid organs, and a little on CD4+CD25+ T cells, macrophages and dendritic cells, and its ligand is GITRL. GITR/GITRL has many important biological activities, including cell proliferation, differentiation and survival.

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