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About Glucagon Like Peptides

All of these physiological effects underscore GLP-1 as a promising therapeutic agent for treating type 2 diabetes. However, the endogenous GLP-1 has a very short half-life (approximately 2 minutes) due to degradation by the ubiquitous enzymes, dipeptidyl peptidase-4 (DPP4) and neutral endopeptidases (NEP).One of the most promising GLP-1 receptor agonists is exenatide (exendin-4) which is a DPP-IV-resistant peptide that shares structural homology with GLP-1. Nowadays, a couple of stable GLP-1 agonists have been approved by FDA as a new class of diabetic drugs, including Liraglutide, Albiglutide and Dulaglutide etc. Pramlintide is an analogue of amylin, a small peptide hormone that is released into the bloodstream by the β cells of the pancreas along with insulin after a meal. Like amylin, pramlintide acts centrally and decreases glucagon secretion, slows gastric emptying and induces satiety. It is gained FDA approval as an adjunct to insulin therapy in type 1 and type 2 diabetes.

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