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About HIF Signaling Pathway

Hypoxia-inducible factor-1 (HIF-1) was first discovered by Semenza and Wang in 1992. Named after the hypoxia upregulation of erythropoietin (EPO) gene transcription. The structure of HIF-1 was subsequently established and the coding sequence of its cDNA was determined. With the deepening of the research, the structure, function, upstream and downstream signal path and metabolic stability of HIF-1 have been further recognized. Studies have found that HIF-1 has a regulatory function on many diseases (tumor, anemia, etc.), especially in the development of tumors. HIF regulates the expression of many tumor growth-transfer factors and plays an important role in tumor cell proliferation, metastasis, invasion, apoptosis, and glucose metabolism. Studies have shown that more than 70% of tumor cells are over-expressed in HIF-1 levels.

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HIF Signaling Pathway Location

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