PI3K Akt Signaling Pathway
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About PI3K Akt Signaling Pathway

The PI3K/Akt signaling pathway is an intracellular signaling pathway that plays an important role in apoptosis, malignancy, tumor progression, metastasis, and radiation therapy. It regulates abnormalities in cancer patients caused by mutations, amplification, deletions, methylation, and post-translational modifications. PI3K/Akt signaling pathway is often activated due to gene mutations and replication number variation (CNAs). P110α is the catalytic subunit of PI3K and is required for tumor cell proliferation, migration and invasion, while p110β is the key to cell survival and tumorigenesis. Therefore, inhibitors of PI3K and other components associated with this pathway are actively used in cancer targeted therapies.

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