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About p53 Signaling Pathway

The p53 gene is an important tumor suppressor gene, and its encoded p53 protein plays a key role in cell cycle regulation, DNA repair, and induction of apoptosis. Mutation of the p53 gene is one of the important factors in tumorigenesis. The p53 gene is mutated in more than 50% of cancer types, which causes the p53 signaling pathway to lose the function of cell growth "brakes". The wild-type p53 protein is located at the intersection of the cell signaling and death signaling networks and plays a decisive role in cell growth, differentiation, senescence, stress, and apoptosis. At the same time, it has intricate relationships with other intracellular signaling pathways. The p53-related target genes verified by a large number of studies mainly include p21, MDM2, CD95/fas, Bax, WT1, p53AIP1, PAG608, HER2, PCNA, cyclin G, and the like. These target genes regulated by the p53 gene directly perform various functions of p53.

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